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Successive aliquots of 0.5 mmol l 1 haemin in N , N -dimethylformamide were added to both the sample cuvette, which contained 10 mol l 1 apo-PGRMC1 (a.a.44195), and the reference cuvette

Innovation 5 , 100722 (2024)

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Concerning the young age of the patient, research on the pathogenic variant in phacomatosis susceptibility genes ( NF1, NF2, SPRED1, SMARCB1, LZTR1) and other 24 genes relevant in the pathogenesis of nervous system tumors ( TP53, EGFR, PDGFRA, PTEN, PIK3CA, PIK3R, RB1, NOTCH1, CDK4, CDKN2A, CDKN2B, IDH1, IDH2, FUBP1 CIC, TACC3, TERTp, ATRX, DAXX, FGFR3, ACVR1, H3F3A, KIAA1549 BRAF) , was performed using a customized gene panel on lymphocyte DNA and tumor tissue