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Decisive evidence that increased adipose tissue lipolysis contributes to nicotine plus HFD-induced hepatic steatosis derives from studies showing that acipimox, an inhibitor of adipose tissue lipolysis, treatment significantly prevented nicotine plus HFD-induced increase in hepatic TG levels and hepatic steatosis (Figure 2) (42)

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Systemic effects Beyond direct hepatic impact, smoking exerts systemic effects that indirectly contribute to liver disease progression

Acknowledgements The authors thank Cambustion Ltd

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