Previous studies showed that NF-B (p65) knockdown could significantly reduce the expression of MMPs and inflammatory factors in chondrocytes that were treated with IL-1 and TNF- 51
Moreover, the SURPASS programme demonstrated that tirzepatide 15 mg is more efficacious in glycaemic control for people with T2D compared to insulin therapies as well as GLP-1 mono-agonists including semaglutide 1 mg and dulaglutide 1.5 mg
doi:10.1080/10408398.2023.2228409
Exendin-4 and exercise improve hepatic glucose homeostasis by promoting insulin signaling in diabetic rats
A drug in development and undergoing clinical trials could be considered prohibited if it falls into one of the categories of banned substances on the WADA Prohibited List, or if it has the potential to be performance enhancing
In a prospective real-world cohort of 194 adults with type 2 diabetes initiating semaglutide or dulaglutide, only 49% achieved 5% weight loss by 12 months meaning that just under half of treated patients did not meet the threshold conventionally defined as clinically meaningful (Vozza et al., 2025)
