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The drug was a paradigm shift in medicine a new class of drugs simultaneously affecting obesity, diabetes and cardiovascular health that rapidly melted off Ellis weight

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The addition of insulin, which usually acts as a vasodilatory agent, did not increase MBV or MBF compared with GLP-1 alone, which suggests the presence of microvascular insulin resistance and the insulin-independent effects of GLP-1 on cardiac microvasculature

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3,533 adults (1,767 in the Ozempic group and 1,766 in the placebo group) were enrolled in the trial conducted in 28 countries at approximately 400 investigator sites