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Glutathione and Amino Acid Metabolism The mechanism of aberrant amino acid metabolism in inducing ferroptosis is indicated as such: the system Xc on the cell membrane consists of a glycosylated heavy chain SLC3A2 and a non-glycosylated light chain SLC7A11, which can exchange extracellular cystine and intracellular glutamate (Glu) in a 1:1 ratio (Yang et al

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10.1093/ajcn/57.5.715S 59