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However, creatine is reversibly converted by creatine kinase into creatine phosphate and is irreversibly cyclized into creatinine through spontaneous loss of one molecule of water, as indicated previously

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Meta-analyses indicate that high blood pressure is associated with an elevated risk of AD and vascular dementia (VAD), while coronary artery disease (CAD) and heart failure (HF) are linked to accelerated cognitive decline, particularly affecting memory, executive function, and processing speed

IRE1/JNK inhibition reduced blood urea nitrogen (BUN), creatinine levels, and renal tissue damage in I/R mice while normalizing ferroptosis biomarkers (e.g., 4-HNE and GPX4)