AN: Data curation, Investigation, Methodology, Writing original draft
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Identified modulation of 4,000+ genes, suggesting potential resetting of cell patterns toward younger phenotypes
In experimental stroke models, platelet aggregometry and thromboelastography (ROTEM) demonstrated activity of vWF that cross links platelets in arterial thrombi, the end product of the coagulation cascade that promotes clot formation [34]
The proposed clinical trial endpoints are the resolution of steatohepatitis without worsening or liver fibrosis and/or improvement in liver fibrosis one stage or greater without worsening of steatohepatitis
Given that M-cells have well-accepted BT capability and overlie intestinal lymphoid aggregates, M-cell mediated BT is one plausible mechanistic explanation [16, 17]