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The carcinogens of tobacco smoke are thought to cause direct and indirect DNA mutations, and indirect DNA damage which disturbs the cellular processes 22 and switches tumor suppressor genes or oncogenes, on or off, and related to the development of OSCC 26

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The heat was stifling in the crowded room

Yet, given the immense health burden of oral cancer and one of the highest prevalence globally, India still lacks the infrastructure to accurately record the cause of deaths in a central database

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Furthermore, long-term nicotine delivery has been shown to slow-down proteinuria by reducing glomerulosclerosis and interstitial fibrosis [297, 300,301,302]