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Although we didnt elucidate the detailed mechanism of how Sema4D was upregulated by smoking, our data indicated that smoking increased Sema4D on CD8 + T cells in peripheral white blood cells, CLN (the draining lymph nodes of the eye involved in many ocular immune diseases 41,42 , and the lung, but not in other solid organs

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Li Q, Wang Y, Ma T, Liu X, Wang B, Wu Z, et al

The both smiled back