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In a subsequent study in young beagle dogs, oral ciprofloxacin doses of 30 mg/kg and 90 mg/kg ciprofloxacin (approximately 1.3-times and 3.5-times the pediatric dose based upon comparative plasma AUCs) given daily for 2 weeks caused articular changes which were still observed by histopathology after a treatment-free period of 5 months

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doi: 10.1038/s41556-020-00579-5 51 ZubkovaEKalininABolotskayaABeloglazovaIMenshikovM

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Starkey F, Audrey S, Holliday J, Moore L, and Campbell R