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JAMA (2006): Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial

Or perhaps Nicholson is the freethinking, rebellious Hollywood legend who thus far in his career has garnered two Oscars, 13 Academy Award nominations and a half-dozen Golden Globe awards, and who is presently commanding so much money per film that it's absolutely indecent