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While e-cigarettes have been grabbing the headlines, the vape pen industry has been quietly ballooning

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Data on rates in former and current smokers and by histological type are even more limited

Nevertheless, the potential for DDIs is rooted in the fact that metformin is a substrate of at least two OATs encoded by the SLC22A gene family (Kimura et al., 2005)

The alternative is, unreasonably, called the inverted plot

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