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Under IL-4 stimulation, the activation of its transcription factor STAT6 induced the secretion of PPAR-coactivator protein 1 (PGC-1), which triggered the production of key components of mitochondrial respiration (67, 68), considered critical for the metabolic switch of M2 macrophages

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Nicotine in diseases Smoking inserts a high amount of xenobiotics, which in turn can alkylate DNA, activate specific (anti)inflammatory signals, and oxidative stress in active smokers and also second-hand smokers [167, 168]

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