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DISCUSSION The current investigation aimed to employ a two-step Mendelian randomization study to examine the genetic associations among irritability, smoking, and bipolar disorder and to analyze the mediation effect

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Both to support those looking to quit, and to prevent youth from using tobacco in the first place

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The study was carried out by Dr Constantino Macias Garcia and his team at St Andrews University

With this background, we undertook an approach by devising and implementing an interrupted time-series model that accounted for the influence of both the tobacco tax increase and the COVID-19 pandemic as interventions