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Twenty studies with control groups were included in a random-effects meta-analysis that found a negative effect of e-cigarette use on cessation (OR = 0.72

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& Bazargan, M

Most of the studies (12 of 14) measured puffing topography in controlled environments, where puffing behavior may or may not represent e-cigarette use behavior in the real world. Two observational studies characterized puffing topography of experienced e-cigarette users of first-generation devices in their naturalistic environments