tobacco's main ingredient is Poisonous Ingredients In Tobacco Smoke Display and that items are being created in safe manner Tobacco - Wikipedia

In parallel, combined exposure also results in global DNA hypomethylation, a hallmark of many cancers ( Together, these epigenetic alterations, including site-specific methylation changes and global DNA hypomethylation, destabilize the genome, silence tumor suppressor genes, and enhance the metabolic activation of carcinogens

A number of these latch onto DNA strands inside cells and scramble the instructions that control how those cells grow, divide, and die

Something serious came up, he wrote

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[170] In the 19th century smoking was common as a symbol of simple pleasures