The body responds by producing localized excess melanin, the same post-inflammatory hyperpigmentation mechanism that causes dark spots on lips after any form of trauma
Normal lips have melanin distributed evenly as part of their natural pigmentation, with healthy blood flow giving them a pink or rosy undertone
As Secretary of Health, Education, and Welfare Joseph Califano, Jr., ruefully noted in the late-1970s when he stepped up the federal governments campaign against smoking, Women who smoke like men, die like men. By 1985, lung cancer had surpassed breast cancer as the leading cause of cancer deaths among women
After a public comment period as well as listening sessions, the final rule was sent to the White House for review in October 2023
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