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This growth is fueled by increasing health awareness and a shift towards vaping as a less harmful alternative to smoking

Smoke Signals Cigarette Cards from the 19th and 20th Centuries One of the earliest forms of direct-to-consumer advertising was trade cards (or tradesman cards), probably first issued in the US in the 1840s

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But other than its addictive properties (which incidentally appear reduced when separated out from other chemicals resident in the smoke) nicotine is a relatively benign drug

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"The process is inherently unpredictable (and possibly political), but we believe the guidelines point to real hurdles to approval," Lavery wrote in an investor note cited by ABC News