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In addition to the dysbiosis of oral microbiota induced by exclusive EC use, studies have further explored the synergistic effects of combined EC consumption with various types of tobacco products on oral microbial communities and their associations with oral pathologies

Prevalence of Chronic Diseases and Cigarette Smoking Compared to nonsmokers, current and former smokers were 5.5 times more likely to have chronic lung disease, 2.8 times more likely to have heart disease, 1.7 times more likely to have diabetes, 1.3 times more likely to have high blood pressure, 1.2 times more likely to have high cholesterol, and 1.4 times more likely to have cancer (Figure 1

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