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"Smoking just one cigarette a day significantly increases your risk of cardiovascular disease, experts warn"

If there is a subgroup who completely (or nearly completely) replaces combusted cigarettes with an alternative product, it would be interesting to determine the trajectories of long-term use of the alternative products

To estimate parameters ae in the model, we developed a finely stratified person-years table, with case counts, stratified on race/ethnicity and 5-year intervals of age, and age-dependent variables of pack-years and years-quit