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Public Health Service released "Smoking and Health: Report of the Advisory Committee to the Surgeon General of the Public Health Service." Over the decades, the reports of the Surgeon General have alerted the nation to health risks of smoking and changed the issues from consumer choice to scientific study and research that investigates factors linked to smoking

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10.1177/1179173X241258347 37

doi: 10.1136/tobaccocontrol-2021-056828 141

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Specifically, we assess the performance of Manus and OpenManus (both baseline and medically tailored versions) against state-of-the-art zero-shot LLMs, including GPT-4.1, Qwen-3, Gemma-3, MedGemma, and Llama-4