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revealed that both tobacco and electronic cigarette inhalation significantly increased markers of oxidative stress (sNox2-dp, H2O2, and 8-iso-PGF2a levels) and platelet activity (sCD40L and soluble P-selectin), and decreased markers of NO bioavailability and antioxidants (Vitamin E) in tobacco smokers classified as healthy (23), Similarly, Mobarrez et al