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These experiments revealed that CSE or E-liquid exposure profoundly altered the proteins present within these BCEVs, with a concomitant increase in the ability of CSE-EVs and MEL-EVs in particular to provoke inflammation, oxidative stress, and DNA damage in recipient urothelial cells

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It is possible JUULs products have only small amounts of pulegone, alleviating concerns, or perhaps more, Jordt said, but we cannot know in the absence of absolute concentrations of pulegone in the e-cigarette liquids.It is fairly simple for flavor chemists to redesign flavor mixes omitting pulegone, using synthetic mint oils, so it is hard to understand why the industry is so sensitive about it, Jordt told ABC News

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Consider these key differences: Cigarette nicotine delivery: Sharp spike within 1020 seconds 12 mg absorbed per cigarette Concentrated smoking sessions 5% vape nicotine delivery: Steadier absorption over time Variable absorption per puff Continuous use throughout the day It's hard to give a perfect one-to-one answer because nicotine absorption differs between smoking and vaping, with factors like vaping habits, puff duration, and individual tolerance influencing absorption