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As he prepares to return to the directors chair, Penn remains grounded in the work, even as he keeps a wary eye on the anguish in the world. This transcript was edited for space and clarity

I was refused interviews by several adults (to whom I had introductions from friends) who feared that I would be as exploitative as the Amish in the City program but this was a minority of adults whom I approached

Many other products have yet to be authorized, despite a plan to fast-track the clearances

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While they are devoid of tar and a majority of the heavy metal components that make tobacco smoke harmful, recent research presents a growing body of evidence suggesting that ENDs are not as safe as we may think