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The term was often used interchangeably with calcined although calcined pipes typically appear to have been darkened all over, while meerschaum wash pipes were typically left with a pale colour all over, or selectively darkened in some areas only, particularly around the bowl rim

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RNA silencing also plays an important role in formation of mosaic symptoms in tobacco by ToMV infection, defining the marginal regions of dark green tissues in a mosaic leaf (Hirai et al

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