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Most (70%) participants in our study recalled warnings on packs, consistent with a study in Karnataka conducted shortly after the larger warnings (covering 85% of the main display areas) appeared on packs 31 , but much higher than in research prior to larger warnings being required, where awareness was less than 40% 32

Although up-regulation of NFE2L2 itself was not detectable under these in vivo conditions, there was significant up-regulation of NFE2L3 and the downstream target Akr1C18 (Supplemental Table XIX) which has been previously linked to prostaglandin metabolism

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