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Although evidence for the cardiopulmonary toxicity of chronic e-cig use is largely restricted to animal studies, investigations in both animals and humans indicate that e-cigs promote hypertension, autonomic imbalance, and vascular dysfunction via nicotine and/or flavors 14,15,16,17,18

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These mitochondrial changes were accompanied by increased pro-inflammatory activity in long-term CSE-exposed cells, as reflected by higher levels of the pro-inflammatory cytokines IL-1, IL-6 and IL-8

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[DOI] [PubMed] [Google Scholar] 5.Griesbach D, Amos A, Currie C