Nicotine increases codeine analgesia through the induction of brain Cyp2d and central activation of codeine to morphine
The tobacco is carefully selected to provide a complex flavour profile, with notes of nuttiness, sweetness, and spice that create a rich and robust smoking experience
Supplementary datasets supporting the analyses of this study are provided with the paper
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Most withdrawal symptoms peak in the first 3 to 10 days and gradually improve within 2-4 weeks
