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Given the limited number of available studies, the lack of a control group in almost all current studies, the absence of long-term prospective data, and the relatively recent introduction of these products, the long-term implications of nicotine pouches in oral carcinogenesis remain unclear

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These studies included one prospective cohort, one case-cohort, and 20 case-control studies with sample sizes ranging from 219,444 to 99

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