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[205] During this period, Wynette also underwent surgeries to remove nodules on her vocal cords and a surgery for a kidney problem

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Material and methods Reagents and chemicals Rutin hydrate HPLC grade was procured from Sigma Aldrich USA

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Furthermore, chronic nicotine use may disrupt Homocysteine (Hcy) metabolism, resulting in Hyperhomocysteinemia and Homocystinuria, which are linked to several diseases including cardiovascular disease, cerebrovascular disease, diabetes, cognitive decline, osteoporosis, and various neurodegenerative disorders (Iqbal and Yakub 2013