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This is especially relevant from a public health perspective as our study examined young adults beginning at age 20 years and included decades of follow-up, said senior author Dr

TIMP2 inhibits MMP-1, MMP-2, MMP-8, and MMP-11, suggesting colchicine reducing the expression of some MMPs and keeping TIMP2 expression high can suppress MMPs mediated tissue modulation and inflammation [18]

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Addressing these gaps could lead to new insights into how mucus plugs develop and how we can better treat them in diverse patient groups