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Abbreviations ACE2: Angiotensin-converting enzyme 2 ALI: Air-liquid interface COPD: Chronic obstructive pulmonary disease COVID-19: Coronavirus disease 2019 CS: Cigarette smoke CSM: Cigarette smoke medium FOXJ1: Forkhead box J1 HBEC: Human bronchial epithelial cell hpi: Hours post-infection IFN: Interferon IL: Interleukin ISG15: Interferon-stimulated gene 15 Kif27: Kinesin-like protein 27 MOI: Multiplicity of infection MUC5AC: Mucin 5AC MxA: Myxovirus resistance protein 1 SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 SEM: Standard error of mean STK36: Serine/threonine kinase 36 TCID 50 : 50% Tissue culture infectious dose TEM: Transmission electron microscopy TMPRSS: Transmembrane serine protease TNF-: Tumor necrosis factor ZO-1: Zonula occluden-1 References WHO