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Some drugs affected by the CYP1A2 isoenzyme system include psychiatric medications (eg, clozapine, olanzapine, imipramine, diazepam, ramelteon), antihypertensive drugs (eg, propranolol, verapamil), opioid analgesics (eg, propoxyphene), anticoagulants (warfarin), and drugs used to treat asthma and other respiratory problems (eg, theophylline)

The FDA called the rise in use among youth especially startling. Today, more than 10 million Americans use e-cigarettes

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[19] Encouraging People to Stop Smoking. World Health Organization, Department of Mental Health and Substance Dependence