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Otherwise, NE increased superoxide production in human peripheral blood mononuclear cells via NOX activation and ROS production ( 3.5 RAAS and immune system ANG-II can cause dysregulations of the adaptive immune system through the stimulation of macrophages and other immune cells mediated by signalling through AT1R ( via AT1R in various cell types, such as the kidney, vasculature, and central nervous system, resulting in an inflammatory immune response ( 3.6 RAAS and insulin resistance ANG II causes hyperinsulinemia and insulin resistance (Zhou et al., 2012

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