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These events included in the endpoint were adjudicated by a blinded, independent committee

23 Notably, it prohibited sale of tobacco products to anyone younger than 18 (and 18 US states now require buyers to be at least 21

Teens and young adults are uniquely vulnerable to the effects of nicotine, and more likely to get addicted

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Psychological complications The same study that found e-cigarettes to increase the risk of heart attack by 55% also found that e-cigarette use may increase a persons risk of depression by 50%