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In May of 2016, the Tobacco Products Directive (TPD) came into force in EU member states
BMJ Open 7 , e014099 (2016)
Stretch here shows up as inconsistent rod diameter long before the tape itself looks worn, which is why weight variance on the line is often a tape problem rather than a tobacco or weight-control issue
Abbreviations ALI: Airliquid interface BALF: Bronchoalveolar lavage fluid BK: Large conductance, Ca 2+ -activated, and voltage-dependent K + CBF: Ciliary beat frequency CFTR: Cystic fibrosis transmembrane conductance regulator COPD: Chronic obstructive pulmonary disease e-cig: E-cigarette FOXJ1: Forkhead box protein J1 HBEC: Human bronchial epithelial cells IL-6: Interleukin-6 IL-8: Interleukin-8 KRT5: Keratin 5 MMP-9: Matrix metalloproteinase-9 MUC5AC: Mucin 5AC MUC5B: Mucin 5B PG: Propylene glycol SCGB1A1: Secretoglobin family 1A member 1 TGFB1: Transforming growth factor-beta1 VG: Vegetable glycerin References Jerzynski, T., Stimson, G
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