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8 IL-13 plays a key role in programming Th2 response and M2 activity

Tobacco-specific nitrosamines (TSNAs), particularly N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which are present at high concentrations in most smokeless tobacco products, are classified as carcinogenic to humans (Group 1) by the International Agency for Research on Cancer (28)

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