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Concomitant increase of tissue Injury/repair markers MMP 9 (11-fold) and TIMP1 (ninefold) was also detected (Fig

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111 Although the exact mechanisms of the influence of CS on the body are still unknown, adverse reactions to the cellular immune response are associated with exposure to aromatic compounds, heavy metals, nicotine, and other toxins

Consequently, there will be fewer instances of acidic contents refluxing back into the esophagus through the LES, weakening the disease defense mechanisms responsible for preventing acid from flowing back