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53,54 Of note, nicotine itself has no effect on the CYP enzymes, and nicotine replacement formulations do not affect the serum levels of coadministered medications like tobacco smoking does

Many of the chemicals produced from smoking can get stuck in the lungs, such as tar, that don't start to clear out until you quit smoking, but the evidence for how long it takes to get tobacco smoke particles out from the lungs indicates anywhere between 18 to 90 seconds, with a mean number of breaths required to wash tobacco smoke particles of 8.7 (1)

Quitting smoking undoubtedly increases life expectancy and reduces the risk of smoking-related diseases

This is typically why most doctors recommend weaning off nicotine slowly with nicotine replacement therapy to increase the chances of long-term success