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Flavored cigarettes appeal directly to youth and non-smokers because they mask the harsh taste of tobacco smoke and ease initiation into smoking

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 World Health Organization (WHO) International Agency for Research on Cancer (IARC), Title: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 89, Smokeless Tobacco and Some Tobacco-specific N -Nitrosamines, Lyon, France, 2007, Historical Overview 1.1.2 Snuff taking, pp

The study also revealed at least 5 distinct processes of DNA damage due to cigarette smoking

24 Smokeless tobacco manufacturers regulate the amount of free nicotine in their product by adjusting the pH of the tobacco

Given the limited number of available studies, the lack of a control group in almost all current studies, the absence of long-term prospective data, and the relatively recent introduction of these products, the long-term implications of nicotine pouches in oral carcinogenesis remain unclear

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