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Tobacco company executives even noted that e-cigarettes drove total industry cigarette volumes down about 600 million cigarettes, or about 1 percent, during the first quarter, excluding Internet sales a major avenue for e-cig purchases

Macro-social influences: The effects of prices and tobacco-control policies on the demand for tobacco products

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Additionally, chronic e-cigarette vapor exposure has been shown to alter the physiology of lung epithelial cells and resident immune cells and to promote poor response to viral challenge in mice [11]

Domestic sales of cigarettes dropped 5 percent in 2002