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We may not have had many randomised controlled trials yet, but the evidence is definitely mounting, so why make it difficult for people who want to use them? She also points out theres an uncanny exchange between falls in smoking rates and rising e-cigarette use in the US and the UK that strongly suggests e-cigarettes help people quit

This effect must be accounted for during product development, typically by selecting fill concentrations that remain below the threshold at which fibre interaction becomes detectable by the consumer

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Its a burning sensation that can be mild to severe