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Dependence requires documented clinical criteria typically a pattern of compulsive use, continued use despite harm, tolerance, withdrawal upon cessation, and loss of control
The message is crystal clear: when it comes to vapes and e-cigarettes in Singapore, the safest approach is complete avoidance
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however, due to the pre-existing damage from prior combustible tobacco product use, it is difficult to isolate the cardiovascular effects of e-cigarette use in this population
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