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Melanin overproduction and UV exposure Heat, irritation, and chemical exposure can stimulate melanocytes, leading to melanin overproduction and visible hyperpigmentation

Teenagers and young adults are especially susceptible to long-term health issues as their bodies and brains are still in a critical phase of development

However, drawbacks consist of side effects such as skin irritation from patches, gastrointestinal discomfort from gum or lozenges, and the potential for continued nicotine dependence if not used as directed

Surgeon General's Reports classify the strength of causal inferences in a four-level hierarchy based upon work of the IOM (now the National Academy of Medicine) and the International Agency for Research on Cancer (IARC) (Refs

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