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First, it binds to and blocks the brains nicotine receptors

The NHSDA Report: Tobacco Use, Income, and Educational Level

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Similarly, chewing either 3 pieces of 2 mg nicotine gum or 1.5 pieces of 4 mg nicotine gum would roughly match the nicotine intake from 3 to 6 cigarettes

1 NCI's Smoking 2007, p.7 "Guide to quitting smoking"

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