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Publishing their study in the journal Biological Psychiatry, the authors note that this finding came as something of a surprise, as it had been assumed that long-term exposure to addictive drugs like nicotine produces lasting changes in users brains, leaving them more susceptible to returning to these drugs even after giving up

In fact, tobacco possesses both stimulant and depressant properties, and understanding this dual nature can profoundly impact our approach to addiction treatment and prevention

Similar 2-stage designs have been informative in prior studies evaluating the nicotine delivery and subjective effects of e-cigarettes [59, 19]

1 2 Carlin 2006, p

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