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Silverstein said

Gently twist until the bottom cap comes off

Then what

It should be noted that cigarette smoke not only affects the cardiovascular system but also has other negative effects on health, and e-cigarette aerosols contain much lower amounts of harmful and potentially harmful substances than cigarette smoke 10,25,51

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Even if its difficult to believe that theyll take off on a large scale, anything more positive than an overwhelming rejection by consumers could well encourage the FDA to think more closely about mandatorily reducing nicotine levels