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Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)

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Tobacco Smoking Ironically patients suffering from recurring aphthous ulcers are usually nonsmokers, and there is a lower prevalence and severity of aphthous ulcers among heavy smokers compared to moderate smokers