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Next both the airways and parenchyma were analyzed for the following: Airways: thickness and tissue composition (cytoplasm+nucleus, fibrin, elastin, high- and low- density collagen) Parenchyma: thickness, tissue fraction, mean linear intercept (L m ), equivalent airspace diameter (D 0 ), heterogeneity, and tissue composition (cytoplasm+nucleus, fibrin, elastin, high- and low-density collagen) Results Conclusion CSE over 24-weeks in female Apoe -/- mice impaired lung function with global stiffening of the lung as evidenced by a downward-rightward shift of the PV-loop, decreased C st , with elevated H and G at all levels of P peep as compared to air exposed controls
