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It is particularly known for its marketing campaigns featuring the Marlboro Man, which featured rugged cowboys and outdoor imagery to capture consumers attention

Although high attrition rates in smoking cessation studies are not uncommon, this, together with the use of a continuous smoking phenotype classification, and the absence of financial incentive to study participants, might have further contributed to small sample size in some smoking phenotype subgroup cohorts

The increased oxidative stress induced by e-cigarettes stimulates the production of reactive oxygen species (ROS) in alveolar macrophages, causing lung epithelial damage and neutrophil influx at the injury site, leading to aggravated inflammation, mucus production, destruction of alveolar cells, and airway obstruction, potentially increasing future cardiovascular risks [53, 54]

BMC Public Health

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